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Archive for the ‘Low Testosterone’ Category

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Surprising Factor Behind Sudden Cardiac Arrest

By William Faloon

Most people associate heart attack with coronary artery blockage. Yet 50% of cardiovascular deaths originate from a condition called sudden cardiac arrest, which is the unexpected acute loss of heart function.

Sudden cardiac arrest is usually caused by an electrical disturbance that disrupts the heart’s rhythmic pumping action. When a cardiac arrest happens, blood flow to the entire body stops.

If not immediately treated, sudden cardiac arrest results in cessation of life. Survival rates remain low despite modern resuscitation attempts.

In a groundbreaking 2014 study, researchers measured testosterone and estrogen levels to correlate risk of sudden cardiac arrest. The findings revealed that lower levels of testosterone or higher levels of estrogen in men were strongly associated with greater risk of sudden cardiac arrest.

These revelations are significant because they provide a basis to identify men at risk for sudden cardiac arrest and implement preventative treatments, such as boosting deficient testosterone and suppressing excess estrogen.

This is an excerpt from an article originally published in Life Extension Magazine. Simply click here to read the complete article.

Misguided Medicine

By William Faloon

Massachusetts General Hospital consistently ranks as one of the world’s top medical facilities. It conducts the largest hospital-based research program in the United States. Case reports from Massachusetts General Hospital are routinely published in the prestigious New England Journal of Medicine.

Doctors at Massachusetts General Hospital observed that prescription sales of testosterone increased by 500% in the United States between the years 1993 and 2000 and continue to surge. This prompted these doctors to study the effects of testosterone and estrogen on body composition, strength, and sexual function in men.

The results of this study published in the New England Journal of Medicine confirm Life Extension’s long-standing position that restoring testosterone blood levels to youthful range reduces body fat, increases lean muscle, improves strength, and enhances sexual function.

This is an excerpt from an article originally published in Life Extension Magazine. Simply click here to read the complete article.

Male Menopause

By Abraham Morgentaler, MD, FACS

One of the fastest-growing areas in medicine today is the use of testosterone in men, particularly during the middle years. Most of my academic credentials within medicine come from my work with testosterone, as I was one of the first to recognize that healthy men can experience an age-related natural decline in hormones that affects their sexuality and vitality, and which can be treated successfully with testosterone therapy. Although testosterone has been used since the 1930s, it was a small backwater in medicine until the last 20 years or so. I feel as if I were there at its modern-era birth and have taken a degree of uncertain pride as I’ve watched the field expand. Although I’ve published many articles on the benefits of testosterone, my greatest contribution has been to show that the long-held belief that testosterone is risky for prostate cancer is false. As the fear of testosterone has declined, physicians have become more comfortable with it, leading to a crescendo of interest in its use.

Men Are Also Hormonal

Over the last 10 years, the fastest pharmaceutical sector is testosterone, growing at more than 10% per year. There are a huge number of men out there who have symptoms of low levels of testosterone. As this problem gained attention from physicians about 10 to 15 years ago, there was a push to talk about andropause, a male version of menopause.

I started to use the term low T in the office and during lectures to describe the condition that has otherwise been called hypogonadism, or testosterone deficiency syndrome. My colleagues thought low T was too simplistic a term, but it worked for me and my patients, and I continue to use it. Nonetheless, I was surprised to hear one day that my verbal shorthand had been co-opted by the industry. Now, television and print ads ask, “Is it low T?”

This is an excerpt from an article originally published in Life Extension Magazine.Simply click here to read the complete article.

Testosterone Therapy Reduces Metabolic Syndrome Components In Deficient Men

Friday, November 1, 2013. On October 15, 2013, the International Journal of Clinical Practice reported the finding of Abdulmaged M. Traish, MBA, Ph.D. of Boston University School of Medicine and his associates of a beneficial effect for testosterone therapy in lowering metabolic syndrome and related cardiovascular disease risk in hypogonadal men.

The study included 255 men aged 33 to 69 years who had sought treatment for symptoms related to low testosterone and had low plasma total testosterone levels upon assessment. All men were treated with testosterone at the beginning of the study period, at six weeks, and every twelve weeks thereafter for up to five years. Weight, height and waist circumference were measured at these time points, and blood samples were assessed for lipids, fasting glucose, hemoglobin A1c, C-reactive protein (CRP, a marker of inflammation) and liver enzymes. All but eleven of the men included in the study had three or more metabolic syndrome components, which include increased waist circumference, hypertension, disordered lipids, and insulin resistance.

This is an excerpt from an article originally published in Life Extension Magazine.Simply click here to read the complete article.

Female Hormone Restoration

Until 2002, mainstream physicians routinely prescribed conventional hormone replacement therapy (HRT) in order to alleviate menopausal symptoms such as hot flashes, mood swings, decreased sexual desire, vaginal dryness, and difficulty sleeping, as well as to prevent heart disease and osteoporosis. In 2002, however, the results of a landmark study, the Women’s Health Initiative (WHI), identified dangers associated with conventional hormone replacement therapy in women. More than 160,000 women participated in this observational study. Conventional HRT side effects included a 26% increased risk of breast cancer, 29% increased risk of heart attack, 41% increase in risk for strokes, and a doubling in risk for blood clots relative to the untreated group. Moreover, women receiving conjugated equine (horse-derived) estrogen experienced a six-fold increased risk for uterine cancer. Only those women under 60 years of age who had undergone a hysterectomy (surgical removal of the uterus) experienced a reduction in breast cancer risk when using estrogen without medroxyprogesterone acetate (MPA), a synthetic progestogen (Rossouw 2002; Grady 2002; Hulley 2002; Azoulay 2004; Moskowitz 2006; Ragaz 2010).

Given the substantial risks associated with conventional HRT, many women began to seek alternatives. Up to 70% of women taking HRT stopped and overall, women’s trust in the mainstream medical establishment declined significantly (Roumie 2004; Schonberg 2005). Data from the study also resulted in many physicians discouraging the use of conventional HRT for the prevention of osteoporosis and cardiovascular disease in aging women (Sharma 2003; Azoulay 2004).

Life Extension was not surprised by the results of the WHI study. The hormones being utilized consisted of oral equine (horse) estrogen and a synthetic progestogen, both of which differ in chemical structure from the natural hormones produced in a woman’s body. Life Extension has discouraged the use of conventional HRT for many years and instead has recognized the value of bioidentical HRT, which uses hormones that are identical as those naturally produced in women. Conventional HRT makes use of non-bioidentical hormones that differ chemically from those naturally produced by a woman’s body. Furthermore, the relative levels of the female hormones administered in conventional HRT are different (Turgeon 2006; Chlebowski 2010).

This is an excerpt from an article originally published in Life Extension Magazine. Simply click here to read the complete article.

Male Hormone Restoration

The significance of testosterone for the male sexual function is apparent to most Life Extension customers. New insights, however, underscore the critical role testosterone plays in maintaining youthful neurological structure, alleviating depression, as well as inducing fat loss in those who are unable to reduce body weight regardless of diet and exercise.

Recent studies have demonstrated that low testosterone in men is strongly associated with metabolic syndrome, type 2 diabetes, cardiovascular disease (Miner and Seftel 2007), and an almost 50% increase in mortality over a seven-year period (Malkin et al 2010).

Restoring testosterone to youthful ranges in middle-aged, obese men resulted in an increase in insulin sensitivity as well as a reduction in total cholesterol, fat mass, waist circumference and pro-inflammatory cytokines associated with atherosclerosis, diabetes, and the metabolic syndrome (Kapoor et al 2006, Malkin et al 2004, Heufelder et al 2009). Testosterone therapy also significantly improved erectile function (Fukui 2007) and improved functional capacity, or the ability to perform physical activity without severe duress, in men with heart failure (Malkin et al 2007).

This is an excerpt from an article originally published in Life Extension Magazine. Simply click here to read the complete article.

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